Louisville figured win No. 18 was in the bag earlier this week when it held a 23-point lead over Duke midway through the second half.
One monumental collapse later, the No. 16 Cardinals are in the position of trying to halt a two-game slide when they host Clemson on Saturday in Atlantic Coast Conference play.
Louisville coach Chris Mack is hoping there won't be a hangover effect after his team was outscored 35-10 over the final 9:07 to suffer a brutal 71-69 loss to the Blue Devils on Tuesday.