CLEVELAND (AP) Chicago Cubs third baseman Kris Bryant is out of the lineup against the Cleveland Indians two days after being hit on the head by a pitch.

Cubs manager Joe Maddon said before Tuesday night's game that the 2016 National League MVP has a cut above his left eye but no concussion after being hit Sunday by Colorado's German Marquez.

"I think he's fine, but getting hit in the head is a pretty traumatic experience," Maddon said. "Fortunately, it never happened to me, but it happened to him."

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TORONTO (AP) Baseball Commissioner Rob Manfred is encouraged by pace-of-play changes that have limited mound visits and reduced the time between innings at major league games this season.

Speaking in Toronto on Tuesday before the Blue Jays hosted the Boston Red Sox, Manfred said the new rules have sped up games without any disruption. Mound visits without pitching changes averaged 3.79 per game through Sunday, down from 7.41 for the 2017 season.

CHICAGO (AP) Marco Gonzales and four relievers combined on a five-hitter, Mitch Haniger singled home the only run and the Seattle Mariners edged the Chicago White Sox 1-0 Tuesday.

At 5-15, the rebuilding White Sox are off to their worst start since the 1950 season. That year they opened 5-20 en route to a 60-94 finish.

KANSAS CITY, Mo. (AP) Salvador Perez carried his own suitcase up the stairs when he arrived home from a stint at Triple-A Omaha, never once thinking about how perilous the trek was the last time he tried it.

The Royals' All-Star catcher was toting his bags up the stairs after returning from spring training last month when he slipped awkwardly on a step. He wound up straining ligaments in his left knee and has spent nearly a month on the disabled list.

BALTIMORE (AP) The Tampa Bay Rays have to wait at least one more day before taking their swings against former teammate Alex Cobb.

Cobb, now with the Baltimore Orioles, was scheduled to face his old team on Tuesday night before the game was postponed by rain.

ARLINGTON, Texas (AP) Sean Manaea's father is from American Samoa, where he grew up playing cricket and rugby and didn't really know anything about baseball.

The younger Manaea was born in Indiana, loved baseball from an early age and blossomed into a hard-throwing 6-foot-5 lefty who in his last start for the Oakland Athletics threw a no-hitter against the Boston Red Sox .

DENVER (AP) The San Diego Padres have placed first baseman Eric Hosmer on the family medical leave list.

The Padres hope to have him back in the lineup Friday, manager Andy Green said before Tuesday's game against the Colorado Rockies.

KANSAS CITY, Mo. (AP) The Brewers activated catcher Manny Pina from the disabled list and put him into the starting lineup for Tuesday night's series opener against the Kansas City Royals.

They cleared roster space by optioning catcher Jacob Nottingham to Triple-A Colorado Springs.

NEW YORK (AP) Pitcher Tyler Duffey has been brought up from the minor leagues by the Minnesota Twins.

The 27-year-old right-hander allowed three hits and a pair of unearned runs in 11 innings over four relief appearances for Triple-A Rochester this season.